Whilst computed tomography (CT) imaging has been a vital component of injury management, its increasing use has raised concern regarding ionising radiation exposure. This study aims to identify latent classes (underlying patterns) of CT use over a 3-year period following the incidence of injury and [...]
For decades, clinicians and researchers have implemented effective measures to reduce, diagnose, and treat CVD. This includes implementing public education campaigns aimed at improving awareness of the potential preventability of CVDs and accessibility to management. Cardiovascular disease risk calculators to estimate individualized risk have also played a [...]
The objective of this study is to quantify the proportion of melanoma diagnoses (invasive and in situ) in the USA that might be overdiagnosed. In this ecological study, incidence and mortality data were collected from the Surveillance, Epidemiology and End Results 9 registries database. DevCan [...]
Using scoping review methods, we systematically searched multiple online databases for publications in the first year of the pandemic that proposed pragmatic population or health system-level solutions to health inequities. We found 77 publications with proposed solutions to pandemic-related health inequities. Most were commentaries, letters, [...]
Although placebo-controlled trials are considered the gold standard for evaluating the efficacy of healthcare interventions, they can be perceived to be controversial and challenging to conduct for surgical treatments. The SUcceSS trial is the first placebo-controlled trial of lumbar decompression surgery for symptomatic lumbar canal [...]
Short-stay joint replacement programmes are used in many countries but there has been little scrutiny of safety outcomes in the literature. We aimed to systematically review evidence on the safety of short-stay programmes versus usual care for total hip (THR) and knee replacement (KR), and [...]
Prosthetic joint infection (PJI) is a devastating complication of total hip arthroplasty (THA). This study aimed to determine if the anterior approach (AP) influenced the incidence of early PJI in THA compared to posterior approach (PP). Record linkage was performed between state-wide hospitalization data and [...]
Prescription drug monitoring programs (PDMP) are increasingly used to identify people prescribed high-dose opioids. However, little is known about whether PDMPs impact opioid agonist treatment (OAT) uptake, the gold standard for opioid use disorder. This study examined the impact of PDMP implementation on OAT initiation [...]
The purpose of this study is to summarize the literature regarding the performance of mammography-image based artificial intelligence (AI) algorithms, with and without additional clinical data, for future breast cancer risk prediction.
Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy world-wide, affecting approximately 1 in 500 individuals. Current therapeutic interventions comprise lifestyle optimisation, medications, septal reduction therapies and rarely cardiac transplantation. Advances in our understanding of disease-causing genetic variants in HCM and their associated molecular mechanisms have [...]