Breast cancer (BC) mortality has declined over the past 30 years, reflecting improved screening, diagnosis and treatment. Over this period, the proportion of people with de novo metastatic BC (dnMBC) has remained relatively stable at approximately 6% of new BC, with cancer registries reporting incremental [...]
Many guidelines recommend non-drug interventions (NDIs) for managing common conditions in primary care. However, compared with drug interventions, NDIs are less widely known, promoted and used. We aim to (1) examine general practitioners’ (GPs’) knowledge, attitudes and practices for NDIs, including their use of the [...]
We aimed to investigate the immediate effect of best practice education (with and without pain science messages) and structure-focused education on reassurance among people with rotator cuff–related shoulder pain. We conducted a 3-arm, parallel-group, randomised experiment. People with rotator cuff–related shoulder pain were randomised (1:1:1) [...]
Short-stay joint replacement programmes are used in many countries but there has been little scrutiny of safety outcomes in the literature. We aimed to systematically review evidence on the safety of short-stay programmes versus usual care for total hip (THR) and knee replacement (KR), and [...]
Pain is one of the most burdensome symptoms in people with cancer, and opioid analgesics are considered the mainstay of cancer pain management. For this review, the authors evaluated the efficacy and toxicities of opioid analgesics compared with placebo, other opioids, nonopioid analgesics, and nonpharmacologic [...]
We investigated differences in cumulative incidence of first distant recurrence following non-metastatic breast cancer over a time period when new adjuvant therapies became available in Australia. We conducted a health record linkage study of females with localized (T1-3N0) or regional (T4 or N+) breast cancer [...]
In clinical practice, the co-existence of endometriosis and gastrointestinal symptoms is often observed. Using large-scale datasets, we report a genetic correlation between endometriosis and irritable bowel syndrome (IBS), peptic ulcer disease (PUD), gastro-esophageal reflux disease (GORD), and a combined GORD/PUD medicated (GPM) phenotype. Mendelian randomization analyses [...]
Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy world-wide, affecting approximately 1 in 500 individuals. Current therapeutic interventions comprise lifestyle optimisation, medications, septal reduction therapies and rarely cardiac transplantation. Advances in our understanding of disease-causing genetic variants in HCM and their associated molecular mechanisms have [...]
The present study examines the patterns of hospital and emergency department services in conjunction with both pre and post diagnostic periods of CT use, which has not been evaluated to date in adult patients with cancer. The cohort makes use of whole of population data [...]
Basic science has found limited evidence from small studies of genuine positive effects on health and wellbeing outcomes, caused by positive treatment expectations, known as placebo effects.1 Naturally, many researchers and clinicians are curious about how to harness the placebo effect in clinical practice to improve [...]