Although NSAIDs are recommended as a first line analgesic treatment, opioids are very commonly prescribed to patients with low back pain (LBP) despite risks of harms. This study aimed to determine factors contributing to general practitioners’ (GPs’) prescribing choices to patients with chronic LBP in [...]
Total hip and knee arthroplasties are common surgeries performed worldwide, but the management of pain during the subacute period (defined as hospital discharge to 3 months postoperatively) is poorly understood. This study aimed to determine patients' experiences, facilitators and barriers to subacute pain management following total [...]
The prevalence of neonatal abstinence syndrome is increasing, but the number and quality of clinical practice guidelines available are unknown. This systematic review aimed to identify, appraise and evaluate clinical practice guidelines for neonatal abstinence syndrome. Methods: A systematic search of databases and the grey [...]
The OPPICO cohort is a population-based cohort based on non-identifiable electronic health records routinely collected from 464 general practices in Victoria, Australia, created with the aim of understanding opioid prescribing, policy impacts and clinical outcomes. The aim of this paper is to provide a profile [...]
Pharmacological interventions are the most used treatment for low back pain (LBP). Use of evidence from systematic reviews of the effects of pharmacological interventions for LBP published in the Cochrane Library, is limited by lack of a comprehensive overview.
Objective To evaluate the comparative effectiveness and safety of analgesic medicines for acute non-specific low back pain.
This overview of systematic reviews summarised evidence on the efficacy, safety, and tolerability of antidepressants for 26 pain conditions. No review presented high certainty evidence on the efficacy of antidepressants. Moderate certainty evidence supported the efficacy of SNRIs, mostly duloxetine at median doses of 60-120 [...]
The risk–benefit balance of opioids versus placebo, paracetamol, NSAIDs, and local or systemic anesthetics is uncertain. Opioids may have equivalent pain outcomes compared with NSAIDs, but evidence on comparisons of harms is very uncertain and heterogeneous. Although factors such as route of administration or dosage [...]
To evaluate the efficacy and safety of opioids for analgesic therapy for people with osteoarthritis. Systematic review and meta‐analysis of randomised, placebo‐controlled trials of opioid therapies for treating the pain of osteoarthritis. The primary outcome was medium term pain relief (six weeks to less than [...]
Understanding barriers and enablers to monitoring and deprescribing opioids will enable the development of tailored interventions to improve both practices. To perform a qualitative evidence synthesis of the barriers and enablers to monitoring ongoing appropriateness and deprescribing of opioids for chronic non-cancer pain (CNCP) and [...]